The effect of surgical treatment for endometrioma on in vitro fertilization outcomes: a systematic review and meta-analysis
Ioanna Tsoumpou, Maria Kyrgiou, Tarek A. Gelbaya, Luciano G. Nardo
Fertility and Sterility® Vol. 92, No. 1, July 2009
Objective: To investigate the effect of surgical treatment of endometrioma on pregnancy rate and ovarian response to gonadotrophin stimulation in women undergoing IVF.
Design: A systematic review and meta-analysis.
Setting: Tertiary referral center for reproductive medicine.
Patient(s): Subfertile women with endometrioma undergoing IVF.
Intervention(s): Surgical removal of endometrioma or expectant management.
Main Outcome Measure(s): Clinical pregnancy rate and ovarian response to gonadotrophins (number of gonado-trophin ampoules, peak E2 levels, number of oocytes retrieved, and number of embryos available for transfer). Result(s): A search of three electronic databases for articles published between January 1985 and November 2007 yielded 20 eligible studies. Meta-analysis was conducted for ﬁve studies that compared surgery vs. no treatment of endometrioma. There was no signiﬁcant difference in clinical pregnancy rate between the treated and the untreated groups. Similarly, no signiﬁcant difference was found between the two groups with regard to the outcome measures used to assess the response to controlled ovarian hyperstimulation with gonadotrophins.
Conclusion(s): Collectively the available data in the literature show that surgical management of endometriomas has no signiﬁcant effect on IVF pregnancy rates and ovarian response to stimulation compared with no treatment. Randomized controlled trials are needed before producing best-practice recommendations on this topic. (Fertil Steril® 2009;92:75–87. copywrigth 2009 by American Society for Reproductive Medicine.)
Key Words: Endometrioma, surgery, IVF, ovarian response, pregnancy outcome
Scarica la pubblicazione